DNA Polymerase II

**Definition:** A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents.

**Tree numbers:** - D08.811.913.696.445.308.300.230

**Synonyms:** - DNA Pol II - DNA Polymerase epsilon - DNA-Dependent DNA Polymerase II