DNA Topoisomerases, Type I

**Definition:** DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.

**Tree numbers:** - D08.811.399.403.483 - D12.776.157.687.375 - D12.776.660.720.375

**Synonyms:** - DNA Nicking-Closing Proteins - DNA Nicking-Closing Protein - DNA Relaxing Enzymes - DNA Relaxing Enzyme - DNA Relaxing Protein - DNA Topoisomerase - DNA Untwisting Enzyme - DNA Type 1 Topoisomerase - DNA Untwisting Enzymes - DNA Untwisting Proteins - DNA Untwisting Protein - Topoisomerase I - Type I DNA Topoisomerase - DNA Topoisomerase I