Ferrochelatase

**Definition:** A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.

**Tree numbers:** - D08.811.520.500 - D12.776.157.427.374.375.957 - D12.776.556.579.374.375.617 - D12.776.575.562

**Synonyms:** - Heme Synthetase - Porphyrin-Metal Chelatase - Protoheme Ferro-Lyase