Fibrinogen

**Definition:** Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

**Tree numbers:** - D12.776.124.050.250 - D12.776.124.125.500 - D12.776.811.300 - D23.119.490

**Synonyms:** - Coagulation Factor I - Factor I - Blood Coagulation Factor I