Folic Acid Antagonists

**Definition:** Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)

**Tree numbers:** - D27.505.519.389.350

**Synonyms:** - Folic Acid Antagonist - Antifolate - Dihydrofolate Reductase Inhibitor - Antifolates - Dihydrofolate Reductase Inhibitors