Formate-Tetrahydrofolate Ligase

**Definition:** A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.

**Tree numbers:** - D08.811.464.259.550

**Synonyms:** - Formyltetrahydrofolate Synthetase - Tetrahydrofolate Formylase