Tourette Syndrome

**Definition:** A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)

**Tree numbers:** - C10.228.140.079.898 - C10.228.662.825.800 - C10.574.500.850 - C16.320.400.820 - F03.625.992.850

**Synonyms:** - Multiple Motor and Vocal Tic Disorder, Combined - Tic Disorder, Combined Vocal and Multiple Motor - Tourette Disease - Tourette Disorder - Tourette's Disease - Tourette's Disorder - Tourette's Syndrome - Chronic Motor and Vocal Tic Disorder - Gilles De La Tourette's Syndrome - Gilles de la Tourette Disorder - Combined Multiple Motor and Vocal Tic Disorder - Combined Vocal and Multiple Motor Tic Disorder - Gilles de la Tourette Syndrome - Gilles de la Tourette's Disease