Glioblastoma

**Definition:** A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

**Tree numbers:** - C04.557.465.625.600.380.080.335 - C04.557.470.670.380.080.335 - C04.557.580.625.600.380.080.335

**Synonyms:** - Astrocytoma, Grade IV