Glucose-6-Phosphate Isomerase

**Definition:** An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.

**Tree numbers:** - D08.811.399.475.200.350

**Synonyms:** - Glucosephosphate Isomerase - Isomerase, Glucose 6 Phosphate - Phosphoglucose Isomerase - Phosphohexose Isomerase