Glutamate Decarboxylase

**Definition:** A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.

**Tree numbers:** - D08.811.520.224.125.250

**Synonyms:** - Glutamate Carboxy-Lyase - Glutamic Acid Decarboxylase