Heme Oxygenase (Decyclizing)

**Definition:** A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt.

**Tree numbers:** - D08.811.682.690.708.410

**Synonyms:** - Heme Oxygenase - Haem Oxygenase