Hemoglobin, Sickle

**Definition:** An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

**Tree numbers:** - D12.776.124.400.463.588 - D12.776.422.316.762.426.588

**Synonyms:** - Hemoglobin S