Histone Deacetylases

**Definition:** Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.

**Tree numbers:** - D08.811.277.087.520

**Synonyms:** - HDAC Proteins - Histone Deacetylase