Job Syndrome

**Definition:** Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.

**Tree numbers:** - C15.378.553.774.600 - C16.320.798.688 - C20.673.774.600 - C20.673.795.688

**Synonyms:** - Buckley Syndrome - HIE Syndrome - Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant - Hyper-IgE Syndrome - Hyperimmunoglobulin E, Recurrent Infection Syndrome - Hyperimmunoglobulin E-Recurrent Infection Syndrome - Hyperimmunoglobulinemia E Syndrome - Job's Syndrome - Job-Buckley Syndrome