Leucyl Aminopeptidase

**Definition:** A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.

**Tree numbers:** - D08.811.277.656.350.100.511 - D08.811.277.656.350.555.700 - D08.811.277.656.675.555.700

**Synonyms:** - Cytosol Aminopeptidase - L-Leucylnaphthylamidase - Leucine Aminopeptidase - Zinc-Manganese-Leucine Aminopeptidase - Peptidase S