Lymphocyte Activation

**Definition:** Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

**Tree numbers:** - E01.370.225.812.482 - E05.200.812.482 - E05.478.594.530 - G12.450.050.400.545 - G12.565

**Synonyms:** - Blast Transformation - Blastogenesis - Transformation, Lymphocyte - Lymphocyte Transformation - Transformation, Lymphoblast - Lymphoblast Transformation - Transformation, Blast - Lymphocyte Stimulation