Multiple Myeloma

**Definition:** A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.

**Tree numbers:** - C04.557.595.500 - C14.907.454.460 - C15.378.147.780.650 - C15.378.463.515.460 - C20.683.515.845 - C20.683.780.650

**Synonyms:** - Myeloma, Plasma-Cell - Myeloma-Multiple - Myeloma, Multiple - Plasma Cell Myeloma - Kahler Disease - Myelomatosis