Neuritis, Autoimmune, Experimental

**Definition:** An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)

**Tree numbers:** - C10.114.703.700 - C10.668.829.650.500 - C20.111.258.625.700 - E05.598.500.500.875

**Synonyms:** - Experimental Allergic Neuritis - Neuritis, Experimental Allergic - Autoimmune Neuritis, Experimental - Experimental Autoimmune Neuritis - Allergic Neuritis, Experimental - EAN (Experimental Allergic Neuritis) - EAN (Experimental Autoimmune Neuritis) - Neuritis, Experimental Autoimmune - Experimental Autoimmune Neuropathy