Nitric Oxide

**Definition:** A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

**Tree numbers:** - D01.339.409.500 - D01.625.550.500 - D01.625.700.500 - D01.650.550.587.600 - D02.389.508.500

**Synonyms:** - Nitrogen Monoxide - Mononitrogen Monoxide - Endogenous Nitrate Vasodilator - Nitric Oxide, Endothelium-Derived