Lactase-Phlorizin Hydrolase

**Definition:** A multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.

**Tree numbers:** - D08.811.277.450.410.100.500.500 - D08.811.277.450.420.475 - D08.811.641.761

**Synonyms:** - Lactase-Glycosylceramidase