Prekallikrein

**Definition:** A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.

**Tree numbers:** - D08.622.658 - D08.811.277.656.300.760.442.725 - D08.811.277.656.959.350.442.725 - D12.776.124.125.597.712 - D12.776.811.243.658 - D23.119.597.712

**Synonyms:** - Fletcher Factor - Kallikreinogen - Plasma Prokallikrein