Progeria

**Definition:** An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.

**Tree numbers:** - C16.320.488.875 - C16.320.565.753 - C18.452.648.753

**Synonyms:** - Hutchinson-Gilford Syndrome - Hutchinson Gilford Progeria Syndrome - Hutchinson-Gilford Progeria Syndrome