Procollagen-Proline Dioxygenase

**Definition:** A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.

**Tree numbers:** - D08.811.682.690.416.617.750 - D08.811.682.690.708.694.750

**Synonyms:** - Procollagen Prolyl 4-Hydroxylase - Protocollagen Prolyl Hydroxylase