Purpura, Thrombotic Thrombocytopenic

**Definition:** An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases.

**Tree numbers:** - C15.378.100.802.687.680 - C15.378.140.855.925.750.680 - C15.378.243.937.925.750.680 - C15.378.925.850 - C23.550.414.950.687.680 - C23.888.885.687.687.680

**Synonyms:** - Thrombotic Thrombocytopenic Purpura - Purpura, Thrombotic Thrombopenic - Moschkowitz Disease - Moschcowitz Disease