Pyrrolizidine Alkaloids

**Definition:** A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.

**Tree numbers:** - D03.132.716 - D03.633.100.772

**Synonyms:** - Pyrrolizidine Alkaloid