Renin

**Definition:** A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.

**Tree numbers:** - D08.811.277.656.074.500.780 - D08.811.277.656.300.048.780 - D08.811.277.656.837.750

**Synonyms:** - Angiotensin-Forming Enzyme - Angiotensinogenase