Shy-Drager Syndrome

**Definition:** A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)

**Tree numbers:** - C10.177.575.550.750 - C10.228.140.079.612.700 - C10.228.662.550.700 - C14.907.514.741

**Synonyms:** - Autonomic Failure, Progressive - Idiopathic Orthostatic Hypotension, Shy-Drager Type - Orthostatic Hypotension, Dysautonomic - Dysautonomia-Orthostatic Hypotension Syndrome - Syndrome, Dysautonomia-Orthostatic Hypotension