Sphingomyelin Phosphodiesterase

**Definition:** An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.

**Tree numbers:** - D08.811.277.352.640.750

**Synonyms:** - Sphingomyelin Cholinephosphohydrolase - Sphingomyelin Cleaving Enzyme - Sphingomyelinase - Sphingomyelinase C