Farnesyl-Diphosphate Farnesyltransferase

**Definition:** The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.

**Tree numbers:** - D08.811.913.225.431

**Synonyms:** - Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase - FPP-FPP Farnesyl Transferase - Presqualene-Diphosphate Synthase - Squalene Synthase - Squalene Synthetase