Steroid 11-beta-Hydroxylase

**Definition:** A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

**Tree numbers:** - D08.244.453.484.750 - D08.244.453.915.750 - D08.811.682.690.708.170.425.750 - D08.811.682.690.708.170.915.750 - D12.776.422.220.453.484.750 - D12.776.422.220.453.915.750

**Synonyms:** - Cytochrome P-450(11 beta) - Steroid 11 Hydroxylase - Steroid-11-Hydroxylase - Steroid 11-Hydroxylase - CYP11B1 - Steroid 11-beta-Monooxygenase - CYP 11B1 - Cytochrome P450 11B1 - 11 beta-Hydroxylase - Cytochrome P-450 CYP11B1