Steroid 12-alpha-Hydroxylase

**Definition:** A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.

**Tree numbers:** - D08.244.453.900.500 - D08.244.453.915.730 - D08.811.682.690.708.170.900.500 - D08.811.682.690.708.170.915.730 - D12.776.422.220.453.900.500 - D12.776.422.220.453.915.730

**Synonyms:** - Steroid-12-Hydroxylase - Steroid-12-Monooxygenase - Steroid 12-Monooxygenase - Cytochrome P450 CYP8B1 - Sterol 12 alpha-Hydroxylase - Sterol 12-alpha-Hydroxylase - 12-alpha-Hydroxylase - 12alpha-Hydroxylase - Cytochrome P450 8B1 - Steroid 12-Hydroxylase - CYP8B1