Supranuclear Palsy, Progressive

**Definition:** A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)

**Tree numbers:** - C10.228.140.079.882 - C10.228.662.700 - C10.292.562.750.500 - C10.574.945.500 - C10.597.622.447.690 - C11.590.472.500 - C23.888.592.636.447.690

**Synonyms:** - Palsy, Progressive Supranuclear - Progressive Supranuclear Palsy - Richardson's Syndrome - Steele-Richardson-Olszewski Disease - Steele-Richardson-Olszewski Syndrome