T-Lymphocytes, Cytotoxic

**Definition:** Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.

**Tree numbers:** - A11.118.637.555.283.875 - A11.118.637.555.567.550.500.200 - A11.118.637.555.567.569.220.200 - A11.118.637.555.567.569.500.200 - A15.145.229.637.555.283.875 - A15.145.229.637.555.567.550.500.200 - A15.145.229.637.555.567.569.220.200 - A15.145.229.637.555.567.569.500.200 - A15.382.490.555.283.875 - A15.382.490.555.567.550.500.200 - A15.382.490.555.567.569.220.200 - A15.382.490.555.567.569.500.200

**Synonyms:** - Cytotoxic T Cells - Cytotoxic T Lymphocyte - Cytotoxic T-Lymphocytes - Cell-Mediated Lympholytic Cells