Thiotepa

**Definition:** A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

**Tree numbers:** - D02.705.672.875 - D03.383.097.217.935.960

**Synonyms:** - Thiophosphamide - Triethylenethiophosphoramide - Tris(1-aziridinyl)phosphine Sulfide - Thio-Tepa