Trypsin Inhibitor, Kazal Pancreatic

**Definition:** A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.

**Tree numbers:** - D12.644.822.750.500 - D12.776.124.050.850 - D12.776.815.688.500

**Synonyms:** - SPINK1 - Trypsin Inhibitor, Pancreatic Secretory - Trypsin Inhibitor Kazal Pancreatic - Kazal Pancreatic Trypsin Inhibitor - Inhibitor, Tumor-Associated Trypsin - Trypsin Inhibitor, Tumor-Associated - Tumor-Associated Trypsin Inhibitor - Acidic Pancreatic Trypsin Inhibitor - Pancreatic Secretory Trypsin Inhibitor, Kazal - Pancreatic Trypsin Secretory Inhibitor, Kazal - Serine Peptidase Inhibitor, Kazal-Type 1 - Pancreatic Secretory Trypsin Inhibitor - Serine Protease Inhibitor Kazal-Type 1