Tumor Necrosis Factor-alpha

**Definition:** Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

**Tree numbers:** - D09.400.430.965 - D12.644.276.374.500.800 - D12.644.276.374.750.626 - D12.776.124.900 - D12.776.395.930 - D12.776.467.374.500.800 - D12.776.467.374.750.626 - D23.529.374.500.800 - D23.529.374.750.626

**Synonyms:** - TNF-alpha - Tumor Necrosis Factor - TNF Superfamily, Member 2 - Tumor Necrosis Factor Ligand Superfamily Member 2 - TNFalpha - Cachectin-Tumor Necrosis Factor - Cachectin