Wolff-Parkinson-White Syndrome

**Definition:** A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.

**Tree numbers:** - C14.280.067.780.977 - C14.280.123.750.977 - C16.131.240.400.980

**Synonyms:** - Anomalous Ventricular Excitation Syndrome - Auriculoventricular Accessory Pathway Syndrome - False Bundle-Branch Block Syndrome - Ventricular Pre-Excitation with Arrhythmia - Wolf-Parkinson-White Syndrome - WPW Syndrome