2-Isopropylmalate Synthase

**Definition:** An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.

**Tree numbers:** - D08.811.913.050.614

**Synonyms:** - alpha-Isopropylmalate Synthase