2',5'-Oligoadenylate Synthetase

**Definition:** An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.

**Tree numbers:** - D08.811.913.696.445.625

**Synonyms:** - (2'-5')An Polymerase - 2',5'-Oligo(A) Polymerase - 2-5A Synthetase - ATP-(2'-5')oligo(A)adenylyltransferase - 2',5'-Oligo(A) Synthetase - 2,5 Oligoadenylate Polymerase - 2,5 Oligoadenylate Synthetase - 2',5'-Oligoadenylate Polymerase