Phorbol 12,13-Dibutyrate

**Definition:** A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.

**Tree numbers:** - D02.455.849.291.500.510.700

**Synonyms:** - Phorbol-12,13-Dibutyrate