DNA Restriction-Modification Enzymes

**Definition:** Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.

**Tree numbers:** - D08.811.150

**Synonyms:** - Restriction Modification System - DNA Restriction-Modification Enzyme - DNA Restriction Modification Enzyme - DNA Restriction Modification Enzymes - Restriction-Modification System - Restriction Modification Systems - Restriction-Modification Systems