Gastrinoma

**Definition:** A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).

**Tree numbers:** - C04.557.470.200.025.290.500 - C04.588.274.761.500.124 - C04.588.322.475.500.124 - C06.301.761.500.124 - C06.689.667.500.124 - C19.344.421.500.124

**Synonyms:** - Gastrin-Producing Tumor - Islet Cell Tumor, Ulcerogenic - Ulcerogenic Islet Cell Tumor