Giant Cells, Langhans

**Definition:** Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity.

**Tree numbers:** - A11.329.372.380 - A11.500.380 - A11.627.482.380 - A11.733.397.380 - A15.382.670.522.380 - A15.382.680.397.380

**Synonyms:** - Langhans-Type Giant Cells - Langhans Giant Cells