Dideoxyadenosine

**Definition:** A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.

**Tree numbers:** - D03.633.100.759.590.138.325.105 - D13.570.230.229.105 - D13.570.230.500.105 - D13.570.583.138.325.105

**Synonyms:** - 2',3'-Dideoxyadenosine - ddA (Antiviral)