Lymphocyte Function-Associated Antigen-1

**Definition:** An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.

**Tree numbers:** - D09.400.430.890.200.074.937 - D09.400.430.890.200.625.550 - D12.776.395.550.200.074.937 - D12.776.395.550.200.625.550 - D12.776.543.550.200.093.937 - D12.776.543.550.200.625.550 - D12.776.543.750.705.408.600.400 - D12.776.543.750.705.877.550 - D23.050.301.350.074.400 - D23.050.301.350.625.550

**Synonyms:** - Leukocyte Function Associated Antigen-1 - LFA-1 - Integrin alphaLbeta2