Granulocyte-Macrophage Colony-Stimulating Factor

**Definition:** An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

**Tree numbers:** - D09.400.430.775.300 - D12.644.276.374.410.240.375 - D12.776.395.240.300 - D12.776.467.374.410.240.375 - D23.529.374.410.240.375

**Synonyms:** - CSF-2 - CSF-GM - GM-CSF - Colony-Stimulating Factor, Granulocyte-Macrophage - TC-GM-CSF - Histamine-Producing Cell-Stimulating Factor - Tumor-Cell Human GM Colony-Stimulating Factor