Maturation-Promoting Factor

**Definition:** Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.

**Tree numbers:** - D08.811.913.696.620.682.700.646.500.984 - D12.776.167.200.580 - D12.776.476.563.646.500.984

**Synonyms:** - Histone H1 Kinase, Growth-Associated - Histone H1 Kinase, M-Phase-Specific - M Phase-Promoting Factor - Mitosis-Promoting Factor