Mutagenesis, Insertional

**Definition:** Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

**Tree numbers:** - E05.393.420.601.550 - G05.365.590.575 - G05.558.550

**Synonyms:** - Insertional Mutagenesis