Oncogene Protein gp140(v-fms)

**Definition:** Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).

**Tree numbers:** - D12.776.624.664.520.750.650 - D12.776.964.700.750.650 - D12.776.964.775.750.650

**Synonyms:** - fms Oncogene Product gp140 - fms Oncogene Protein gp140 - gp140 v-fms - gp140(v-fms) - v-fms Protein