Neoplasms, Second Primary

**Definition:** Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

**Tree numbers:** - C04.692

**Synonyms:** - Neoplasms, Metachronous - Neoplasms, Metachronous Second Primary - Second Malignancy - Second Neoplasm - Second Primary Neoplasms - Second Primary Neoplasms, Metachronous - Metachronous Second Primary Neoplasms - Metachronous Neoplasms